Ghoulia Yelps decided to help the beauty Cleo de Nile to improve her grades in school and prepare for exams. Who would have thought that Cleo will like science so much! Now girlfriends put experiments nonstop studying chemistry, mixing various reagents that gives often very funny effect. Other students of the Monster High school are very surprised that Cleo is interested not only in fashion, boys and intrigues against the other girls!